Modeling bipolar stimulation of cardiac tissue
نویسندگان
چکیده
منابع مشابه
Biomimetic Electrical Stimulation for Cardiac Tissue Engineering
A major challenge of tissue engineering is directing cells to establish the physiological structure and function of the tissue being replaced. Electrical stimulation has been used to induce synchronous contractions of cultured cardiac constructs. The hypothesis adopted for this study is that functional cardiac constructs can be engineered by "mimicking" the conditions present during cardiac dev...
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Long term responses of the heart to e.g. infarction or surgical intervention are related to response of the tissue to changes in the mechanical environment. The tissue response is likely to involve (local) change of mass. Implementation of the associated inhomogeneous change in volume for a complex geometry is cumbersome. In the present study, we propose a computational framework for finite vol...
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In vitro application of pulsatile electrical stimulation to neonatal rat cardiomyocytes cultured on polymer scaffolds has been shown to improve the functional assembly of cells into contractile engineered cardiac tissues. However, to date, the conditions of electrical stimulation have not been optimized. We have systematically varied the electrode material, amplitude and frequency of stimulatio...
متن کاملDepolarization Diffusion during Weak Suprathreshold Stimulation of Cardiac Tissue
Background: The theory of stimulation of cardiac tissue based on virtual electrode (VE) polarization was presented by Wikswo and his group (Wikswo, Biophys. J., 1995). Four basic regimes were distinguished: anodal make, anodal break, cathodal make, and cathodal break. We sought to determine applicability of this theory for near-threshold stimulus intensities. Methods: For the experiments we use...
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Retinal implants allowing blind people suffering from diseases like retinitis pigmentosa and macular degeneration to regain rudimentary vision are struggling with several obstacles. One of the main problems during external electric stimulation is the co-activation of the ON and OFF pathways which results in mutual impairment. In this study the response of ON and OFF cone retinal bipolar cells d...
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ژورنال
عنوان ژورنال: Chaos: An Interdisciplinary Journal of Nonlinear Science
سال: 2017
ISSN: 1054-1500,1089-7682
DOI: 10.1063/1.5000163